Construction of the 1,5-benzodiazepine skeleton from o-phenylendiamine and propargylic alcohols via a domino gold-catalyzed hydroamination/cyclization process

Abstract

The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives