Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression

Abstract

We thank Dr Carlos Lopez-Otın and Dr Xose S Puente (University of Oviedo, Spain) for kindly providing pcDNA3-human MMP-2, pCEP-Puro-MMP-2 and pCEP-Puro-mutMMP-2 plasmids, and HT-1080 fibrosarcoma cells conditioned medium. We are also grateful to Dr Aurora Astudillo, Marta Sanchez, Marta Alonso and Ana Salas for their technical support. This work was supported by grants from Fondo de Investigación Sanitaria, FICYT and ISCIII,Red de Centros de Cancer RTICCC. The Instituto Universitario de Oncología del Principado de Asturias is supported by Obra Social CajAstur, Asturias, Spain.MC is supported by the Spanish Ministry of Education and Science. MG-A is supported FICYT. VB and MF are supported by Cancer Research UK Beatson Institute core program gran