The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription

Abstract

This work was supported by grant BFU2010-15518 from the Spanish Ministry of Science and Innovation, and the FEDER program of the European Community, and it was performed within the framework of the ‘‘Xarxa de Referencia en Biotecnologia’’ of the Generalitat de Catalunya. It was also supported by the Principado de Asturias Government through PCTI founds 2006-2009, 80% co-financed with the FEDER Operative Program of the Principado de Asturias 2007-2013 (project FC-11-PC-10-31) and Fondo de Investigaciones Sanitarias (Institute Carlos III) PS09/00420 and PI12/01280. A. F-G. is co-financed by the project COF-11-24 from FICYT. C.V. is recipient of a JAE-Predoc2010 fellowship (CSIC), co-financed by the European Social Fund