Rationally designed glycosylated premithramycins: Hybrid aromatic polyketides using genes from three different biosynthetic pathways

Abstract

This work was supported by a grant of the European Union (QLRT-1999-00095) to A.B. and J.A.S. as well as by grants from the U.S. Department of Defense and the National Institutes of Health (R01CA91901) to J.R. Dr. Daniel W. Bearden (Center for Coastal Environmental Health and Biomolecular Research, NOAA, Charleston, SC) is acknowledged for recording the NMR data on diolivosylpremithramycinone