Bone environment is essential for osteosarcoma development from transformed mesenchymal stem cells

Abstract

This work was supported by the Instituto de Salud Carlos III/ Fondos FEDER (PI10/00449 to P.M, PI11/00377FIS to J.G-C, CP11/00024 to R. Rodriguez), Tercel (RD12/0019/0006) and RTICC (RD12/0036/0015 and RD12/0036/0027); the Junta de Andalucia/FEDER (P08-CTS-3678 to P.M.), the MINECO (PLE-2009-0111 to P.M.), The Spanish Association Against Cancer(Junta Provincial de Albacete-CI110023 to P.M.), Grupo Español de Investigacion en Sarcomas (beca J.M. Buesa-2012 to R. Rodriguez), Obra Social Cajastur-IUOPA, EuroNanomed ERANET initiative (REBONE project; PI10/02985FIS to J.G-C.), Comunidad de Madrid (CellCAM; P2010/BMD-2420 to J.G-C.)and Health Canada (H4084–112281 to P.M., R. Rodriguez, and M.R-M). R. Rodriguez and A. Abarrategi are supported, respectively, by the Miguel Servet and Sara Borrell programs of the ISCIII/FEDER. R. Rubio was supported by a fellowship of the ISCIII/FEDER. P.M. is an ICREA Professor supported by the Generalitat of Catalunya.Rubio, R., Abarrategi, A., Garcia-Castro, J., Martinez-Cruzado, L., Suarez, C., Tornin, J., Santos, L., Astudillo, A., Colmenero, I., Mulero, F., Rosu-Myles, M., Menendez, P., Rodriguez, R