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A Bayes Random Field Approach for Integrative Large-Scale Regulatory Network Analysis

By Yinyin Yuan and Chang-Tsun Li

Abstract

We present a Bayes-Random Fields framework which is capable of integrating unlimited data sources for discovering relevant network architecture of large-scale networks. The random field potential function is designed to impose a cluster constraint, teamed with a full Bayesian approach for incorporating heterogenous data sets. The probabilistic nature of our framework facilitates robust analysis in order to minimize the influence of noise inherent in the data on the inferred structure in a seamless and coherent manner. This is later proved in its applications to both large-scale synthetic data sets and Saccharomyces Cerevisiae data sets. The analytical and experimental results reveal the varied characteristic of different types of data and refelct their discriminative ability in terms of identifying direct gene interactions

Topics: Data processing, computer science, computer systems
Publisher: Faculties. Faculty of Technology, Research Groups in Informatics
Year: 2008
OAI identifier: oai:biecoll.ub.uni-bielefeld.de:293

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