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Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin B1 in broiler chickens
Abstract
Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%- journalArticle
- info:eu-repo/semantics/article
- info:eu-repo/semantics/publishedVersion
- Biology and Life Sciences
- Fusarium toxins
- oral bioavailability
- deoxynivalenol
- fumonisin B1
- toxicokinetics
- broiler chickens
- MONILIFORME CULTURE MATERIAL
- MAXIMUM EUROPEAN TOLERANCE
- FUSARIUM-MONILIFORME
- MYCOTOXIN DEOXYNIVALENOL
- TISSUE PERSISTENCE
- MULTI-MYCOTOXIN
- TURKEY POULTS
- AVIAN FEEDS
- LAYING HENS
- TOXICOKINETICS