Comparative phytochemical profile and antiproliferative activity on human melanoma cells of essential oils of three lebanese Salvia species

Abstract

In the Lebanese folk medicine, Salvia species are used by many people in various villages and towns for the therapeutic value of their essential oils and water exts. In this paper we report on the chem. compn. and the potential anticancer effect of essential oils from three Salvia species well known in Lebanon as component in several multiherb products used for the treatment of cancer and other diseases: Salvia aurea L., Salvia judaica Boiss. and Salvia viscosa Jacq. The three essential oils, studied by GC and GC-​MS, were all rich in sesquiterpenes, particularly oxygenated sesquiterpenes, with caryophyllene oxide as main compd. for all three oils. The essential oils biol. activity was evaluated in human melanoma cells testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-​3 activity. All the oils were able to inhibit the growth of the cancer cells examd. inducing apoptotic cell death, thus providing an in vitro scientific support for the use of these plants in traditional herbal prepns