3324 singleton pregnant women screened for preterm delivery and 128 finally randomized and analysed for outcome showing borderline cervical length and elevated cervico-vaginl interleukin 6 levels and verify if vaginal administration of lactoferrin might have an influence on these variables.Our data show that lactoferrin could play a role in reducing the number of women at risk for pre-term birth for shortened cervical length and elevated IL-6 level
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