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Induzione dell’ovulazione con GnRH pulsatile in donne affette da amenorrea ipotalamica

By MARCI R., DESSOLE S., SENN A., DE GRANDI P. and GERMOND M.

Abstract

Ovulation and pregnancy rates following follicular maturation by administration of pulsatile gonadotrophin-releasing hormone (GnRH) were studied in women with hypothalamic amenorrhea (HA). Nine patients were treated for a total of 32 cycles. Pulse of GnRH was administered at a dose of 20 µg/90 min during the follicular phase and 20 µg/120 min after ovulation for up to 5 days . Follicular growth was monitored using estradiol (E2), progesterone (P), luteinizing hormone (LH) assays and vaginal echography. Ovulation was confirmed by E2 level > 0.8 nmol/l, a follicle diameter ≥20 mm and a LH peak. The couples were proposed to have sexual intercourses during the next days; after several unsuccesful cycles some patients were inseminated with washed sperm. Ovulation occurred in 24/32 cycles (75.0%); seven pregnancies (29.1%) were achieved and five full term deliveries (5/7=57.3%). In conclusion, HA patients treated with a 20 µg pulse dose reach ovulation in 75.0% of the cycles.Compared to lower pulse doses, the stimulation length is reduced without leading to either multiple pregnancies or ovarian hyperstimulation syndrome (OHSS)

Year: 1999
OAI identifier: oai:iris.unife.it:11392/1681179
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