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Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.

By Kok SH, Gambari R, Chui CH, Yuen MC, Lin E, Wong RS, Lau FY, Cheng GY, Lam WS, Chan SH, Lam KH, Cheng CH, Lai PB, Yu MW, Cheung F, Tang JC and Chan AS.

Abstract

Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells

Topics: Antiproliferation, Benzothiazole, Neoplasm, Phthalimide
Year: 2008
DOI identifier: 10.1016/j.bmc.2008.02.005
OAI identifier: oai:iris.unife.it:11392/533946
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