Preparation and characterization of collagen sponges for dermo-cosmetic applications

Abstract

In this study we describe (a) the purification of collagen fibers substantially free from the immunogenic non helical terminal portion of collagen (C- and N-terminal portions and telopeptides) and (b) the process for the production of bovine tendon collagen sponges for cosmetic and drug release applications. The self-crosslinking of atelopeptide collagen, based on thermal treatment was obtained after exposure of collagen sponges to elevated temperatures. This system allows the control of both the mechanical properties of collagen self-crosslinked devices and the release profiles of bioactive components. The systems presented here may have several advantages for application in cosmetic as well as for the controlled release of dermatologically active compounds