Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats.

DeGennaro Colonna V; Cocchi D; Maggi A; Müller E.E.; ZOLI, Michele; MARRAMA, Paolo; AGNATI, Luigi Francesco

research article

oai:iris.unimore.it:11380/744232

Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats.

Authors: DeGennaro Colonna V
Cocchi D
Maggi A
Müller E.E.
Michele ZOLI
Paolo MARRAMA
Luigi Francesco AGNATI
Publication date: 1 January 1989
Publisher
Doi

Abstract

Growth hormone releasing factor-like immunoreactivity (GHRF-LI) and GHRF mRNA levels were evaluated in the hypothalamus of aged (24 months) and young (3 months) rats by semiquantitative immunocytochemistry and slot blot hybridization technique, respectively. Simultaneous detection of reduced GHRF-LI and GHRF mRNA levels in aged rats as compared to young counterparts demonstrates the existence in aged rats of an impaired function of GHRF-producing neurons

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Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

oai:iris.unimore.it:11380/7442...

Last time updated on 12/11/2016

This paper was published in Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia.

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