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Hydrolysis of ITP generates a membrane potential in submitochondrial particles.

By Sorgato MC, Galiazzo F, Valente M, Cavallini L and Ferguson SJ


ITP hydrolysis catalysed by the ATPase of submitochondrial particles from both bovine heart and rat liver is shown to be linked to the generation of a membrane potential, and therefore also to proton translocation. The magnitude of the membrane potential is similar to that observed during ATP hydrolysis at equivalent concentrations of phosphate and nucleoside tri- and diphosphates. An explanation is suggested for why in other reports ITP was found to be a poor substrate for supporting energy-linked reactions that are driven by the membrane potential

Year: 1982
DOI identifier: 10.1016/0005-2728(82)90038-X
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