Feline primary osteosarcomas involving the skull are extremely rare. When they occur, orbit, mandible, and maxilla are the most common sites. Microscopically, scattered multinucleated giant cells (MGCs) are not an uncommon occurrence in osteosarcoma (OSC), but they are generally in low number. Only in a rare variant, the giant cell-rich OSC, are MGCs the prevalent cell type. Although osteoclast and osteoblast origin have been postulated in human and veterinary literature, the origin of MGCs in osteosarcomas is poorly understood. This report describes a giant cell-rich OSC in the calvarium of a 13-year-old spayed female shorthair cat. The animal exhibited a range of neurologic signs, including left circling, compulsive gait, lack of proprioception, and bilateral absence of menace reaction, with indication of left forebrain involvement. Gross lesions were characterized by a multilobate, spherical mass located in the left calvarium, compressing the left forebrain. Histologically, the tumor was characterized by scattered nests of MGCs separated by small bundles of pleomorphic, fusate to polygonal cells. Between spindle cells, osteoid was very sparse and arranged in thin strands. Immunohistochemical stains for vimentin were positive, with no detectable cellular staining for cytokeratin, S-100 protein, or Class II major histocompatibility complex. Ultrastructurally, MGCs contained profiles of rough endoplasmic reticulum; no lysosomes were observed. The origin of MGCs in osteosarcoma remains obscure, and our results confirm their ambiguous identity
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.