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The genetic architecture of metabolic rate: environment specific epistasis between mitochondrial and nuclear genes in an insect

By Goran Arnqvist, Damien Dowling, Paul Eady, Laurene Gay, Tom Tregenza, Midori Tuda and David J. Hoskin


The extent to which mitochondrial DNA (mtDNA) variation 25 is involved in\ud adaptive evolutionary change is currently being reevaluated. In particular,\ud emerging evidence suggests that mtDNA genes coevolve with the nuclear\ud genes with which they interact to form the energy producing enzyme\ud complexes in the mitochondria. This suggests that intergenomic epistasis\ud 30 between mitochondrial and nuclear genes may affect whole-organism\ud metabolic phenotypes. Here, we use crossed combinations of mitochondrial\ud and nuclear lineages of the seed beetle Callosobruchus maculatus and assay\ud metabolic rate under two different temperature regimes. Metabolic rate was\ud affected by an interaction between the mitochondrial and nuclear lineages and\ud 35 the temperature regime. Sequence data suggests that mitochondrial genetic\ud variation has a role in determining the outcome of this interaction. Our genetic\ud dissection of metabolic rate reveals a high level of complexity, encompassing\ud genetic interactions over two genomes, and genotype × genotype ×\ud environment interactions. The evolutionary implications of these results are\ud 40 twofold. First, because metabolic rate is at the root of life histories, our results\ud provide insights into the complexity of life history evolution in general, and\ud thermal adaptation in particular. Second, our results suggest a mechanism\ud that could contribute to the maintenance of non-neutral mtDNA polymorphism.\ud Evolution Page 2 of 3

Topics: C182 Evolution
Publisher: Wiley
Year: 2010
DOI identifier: 10.1111/j.1558-5646.2010.01135.x
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