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Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

By Jérôme Nevoux, Marie Teixeira, Say Viengchareun, Claudine Cosson, Daniel Butlen, Marc Lombes and Evelyne Ferrary


International audienceA strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases

Topics: endolymph, vasopressin receptors, Menière's disease, vestibular cells, purinergic receptors, MESH : Adenosine Triphosphate, MESH : Adenylate Cyclase, MESH : Phosphoric Diester Hydrolases, MESH : Potassium, MESH : Receptors, Purinergic P2Y, MESH : Receptors, Vasopressin, MESH : Reverse Transcriptase Polymerase Chain Reaction, MESH : Vasopressins, MESH : Animals, MESH : Blotting, Western, MESH : Calcium Signaling, MESH : Catecholamines, MESH : Cell Line, MESH : Cyclic AMP, MESH : Ear, Inner, MESH : Mice, [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Publisher: Wiley
Year: 2011
DOI identifier: 10.1016/j.febslet.2011.07.025
OAI identifier: oai:HAL:inserm-00656238v1
Provided by: Hal-Diderot

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