Skip to main content
Article thumbnail
Location of Repository

Diversity of intrinsic frequency encoding patterns in rat cortical neurons : mechanisms and possible functions

By Ph.D. Jing Kang, Hugh P. C. Robinson and Jianfeng Feng


Extracellular recordings of single neurons in primary and secondary somatosensory cortices of monkeys in vivo have shown that their firing rate can increase, decrease, or remain constant in different cells, as the external stimulus frequency increases. We observed similar intrinsic firing patterns (increasing, decreasing or constant) in rat somatosensory cortex in vitro, when stimulated with oscillatory input using conductance injection (dynamic clamp). The underlying mechanism of this observation is not obvious, and presents a challenge for mathematical modelling. We propose a simple principle for describing this phenomenon using a leaky integrate-and-fire model with sinusoidal input, an intrinsic oscillation and Poisson noise. Additional enhancement of the gain of encoding could be achieved by local network connections amongst diverse intrinsic response patterns. Our work sheds light on the possible cellular and network mechanisms underlying these opposing neuronal responses, which serve to enhance signal detection

Topics: QL, QA
Publisher: Public Library of Science
Year: 2010
OAI identifier:

Suggested articles


  1. (1999). A network of fast-spiking cells in the neocortex connected by electrical synapses. doi
  2. (2006). A review of the integrate-and-fire neuron model: I. Homogeneous synaptic input. doi
  3. (2003). Correlated neuronal discharges that increase coding efficiency during perceptual discrimination. doi
  4. (2004). Decoding input signals in time domain - A model approach. doi
  5. Destexhe A (2009) The Dynamic-Clamp: From Principles to Applications,; doi
  6. (1992). Differential Responses of 2 Types of Electroreceptive Afferents to Signal Distortions May Permit Capacitance Measurement in a Weakly Electric Fish, doi
  7. (2009). Driving fast-spiking cells induces gamma rhythm and controls sensory responses. doi
  8. (2005). Excitatory cortical neurons form fine-scale functional networks. doi
  9. (2005). Flexible control of mutual inhibition: A neural model of two-interval discrimination. doi
  10. (2003). Flutter discrimination: Neural codes, perception, memory and decision making. doi
  11. (2006). Inhibitory control by an integral feedback signal in prefrontal cortex: A model of discrimination between sequential stimuli. doi
  12. (1993). Injection of Digitally Synthesized Synaptic Conductance Transients to Measure the Integrative Properties of Neurons. doi
  13. (1981). Integrate-and-Fire Models of Nerve Membrane Response to Oscillatory Input. doi
  14. (2009). Integration of Broadband Conductance Input in Rat Somatosensory Cortical Inhibitory Interneurons: An InhibitionControlled Switch Between Intrinsic and Input-Driven Spiking in Fast-Spiking Cells. doi
  15. (2001). Is the integrate-and-fire model good enough? a review. doi
  16. (2002). Model for a robust neural integrator. doi
  17. (1999). Neuronal correlates of parametric working memory in the prefrontal cortex.
  18. (2000). Periodicity and firing rate as candidate neural codes for the frequency of vibrotactile stimuli.
  19. (2000). Postsynaptic variability of firing in rat cortical neurons: The roles of input synchronization and synaptic NMDA receptor conductance.
  20. (2006). Rate coding and spike-time variability in cortical neurons with two types of threshold dynamics. doi
  21. (1994). Responses of Cells in the Mormyrid Electrosensory Lobe to Eods with Distorted Wave-Forms - Implications for Capacitance Detection. doi
  22. (2004). Responses of neurons in the electrosensory lateral line lobe of the weakly electric fish Gnathonemus petersii to simple and complex electrosensory stimuli. doi
  23. (1995). Single-channel recording. doi
  24. (1993). The Dynamic Clamp -Artificial Conductances in Biological Neurons. doi
  25. (2003). Timing and neural encoding of somatosensory parametric working memory in macaque prefrontal cortex. doi
  26. (1999). Two networks of electrically coupled inhibitory neurons in neocortex.
  27. (1999). Variability of firing of Hodgkin-Huxley and FitzHugh-Nagumo neurons with stochastic synaptic input. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.