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LAT Links the Pre-BCR to Calcium Signaling

By Y. Su and H. Jumaa


SLP-65<sup>-/-</sup> mice display a partial block at the pre-B cell stage of development. Here, we show that LAT is required for the differentiation of SLP-65<sup>-/-</sup> pre-B cells. We show that LAT and SLP-76 are recruited to the pre-BCR and associated with Ig-α upon pre-BCR engagement, whereas LAT interaction with SLP-76 is already detected in untreated pre-B cells. Reconstitution of LAT or SLP-65 expression in SLP-65/LAT<sup>-/-</sup> pre-B cells restored their calcium (Ca<sup>2+</sup> mobilization capacity, led to downregulation of surface pre-BCR, and induced differentiation to BCR<sup>+</sup> cells. Together, our results suggest that the adaptor proteins LAT and SLP-76 are involved in pre-BCR signaling, thereby rescuing arrested murine SLP-65<sup>-/-</sup> pre-B cells

Year: 2003
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Provided by: MPG.PuRe
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