Skip to main content
Article thumbnail
Location of Repository

What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?

By P Horby, H Sudoyo, V Viprakasit, A Fox, PQ Thai, H Yu, S Davila, M Hibberd, SJ Dunstan, Y Monteerarat, JJ Farrar, S Marzuki and NT Hien

Abstract

The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation

Publisher: Cambridge University Press (CUP)
Year: 2010
OAI identifier: oai:researchonline.lshtm.ac.uk:2869493
Provided by: LSHTM Research Online
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.1017/S095... (external link)
  • http://researchonline.lshtm.ac... (external link)
  • http://creativecommons.org/lic... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.