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Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients : A Pilot Study

By AP de Ruiter, Nard Janssen, Robert van Es, Michael Frank, Gert Meijer, Ron Koole and Toine Rosenberg

Abstract

OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation. DESIGN: Prospective clinical study. SETTING: University clinic. PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with β-TCP in 2010 and 2011. MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured β-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized. RESULTS: Six months after the operative grafting of micro-structured β-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume. CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured β-TCP bone substitute for repair of the alveolar cleft

Topics: β-TCP, bone grafting, bone regeneration, bone substitute, cleft lip and palate (CLP)
Year: 2015
OAI identifier: oai:dspace.library.uu.nl:1874/335843
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