Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

GRAEBIN, Cedric S.; MADEIRA, Maria de F.; YOKOYAMA-YASUNAKA, Jenicer K. U.; MIGUEL, Danilo C.; ULIANA, Silvia R. B.; BENITEZ, Diego; CERECETTO, Hugo; GONZALEZ, Mercedes; ROSA, Ricardo Gomes da; EIFLER-LIMA, Vera Lucia

research article

oai:agregador.ibict.br.RI_USP:oai:www.producao.usp.br:BDPI/28498

Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

Authors: Cedric S. GRAEBIN
Maria de F. MADEIRA
Jenicer K. U. YOKOYAMA-YASUNAKA
Danilo C. MIGUEL
Silvia R. B. ULIANA
Diego BENITEZ
Hugo CERECETTO
Mercedes GONZALEZ
Ricardo Gomes da ROSA
Vera Lucia EIFLER-LIMA
Publication date: 1 January 2010
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Doi

Abstract

The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives. (C) 2010 Elsevier Masson SAS. All rights reserved

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This paper was published in RCAAP - Repositório Científico de Acesso Aberto de Portugal.

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