Skip to main content
Article thumbnail
Location of Repository

The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

By Taís Nóbrega de Sousa, Flora Satiko Kano, Cristiana Ferreira Alves de Brito and Luzia Helena Carvalho

Abstract

Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania

Topics: malaria, Plasmodium vivax, Duffy binding protein, naturally acquired antibodies, genetic variability
Publisher: Fundação Oswaldo Cruz
Year: 2014
OAI identifier: oai:agregador.ibict.br.RI_FIOCRUZ:oai:localhost:icict/9582
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.rcaap.pt/detail.jsp... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.