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Annals of Diagnostic Pathology

By Paulo Roberto Fontes Athanazio, José do Egypto Pereira Filho, Daniele Meneses de Amorim, Gloria Maria Maranhão Sweet, Luiz Antonio Rodrigues de Freitas and Daniel Abensur Athanazio

Abstract

Texto completo: acesso restrito. p. 397–401Renal angiomyolipoma (AML) may present as rare variants such as epithelioid and AML with epithelial cysts posing difficulties for the diagnosis to the surgical pathologist. We report a case of a 46-year-old male patient presenting a 5-cm solid tumor in the lower pole of the left kidney, with cystic changes at cut surface. The tumor exhibited 95% of epithelioid cells with atypical nuclei. A small focus of typical AML was observed. The immunoprofile of tumor cells was classical of AML including expression of melanocytic markers such as HMB45 and Melan A. We report the immunohistochemical study of the cystic component in an epithelioid AML. In contrast to the immunoreactivity reported in typical AML, the present case shows obvious expression of melanocytic markers in the cystic epithelial lining. This is strong evidence that these cysts are neoplastic and derived from AML, rather than entrapped native collecting duct epithelium

Topics: Angiomyolipoma, Kidney, Perivascular epithelioid cell neoplasms, Immunohistochemistry, Kidney neoplasms
Year: 2014
OAI identifier: oai:agregador.ibict.br.RI_UFBA:oai:192.168.11:11:ri/15138
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