International Journal of Epidemiology

Abstract

p.816–830Diarrhoea is an important cause of death and illness among children in developing countries; however, it remains controversial as to whether diarrhoea leads to stunting. We conducted a pooled analysis of nine studies that collected daily diarrhoea morbidity and longitudinal anthropometry to determine the effects of the longitudinal history of diarrhoea prior to 24 months on stunting at age 24 months. Data covered a 20-year period and five countries.We used logistic regression to model the effect of diarrhoea on stunting.The prevalence of stuntingat age 24 months varied by study(range 21 –90%),as did the longitudinal history of diarrhoea prior to 24 months(incidence range 3.6–13.4 episodes per child-year, pre-valence range2.4–16.3%).The effect of diarrhoea on stunting,however,was similar across studies.The odds of stunting at age 24 months in creased multiplicatively with each diarrhoeal episode and with each day of diarrhoea before 24 months(all P<0.001).The adjusted odds of stunting in creased by 1.13 for every five episodes (95% CI 1.07–1.19),and by 1.16 for every 5%unit increase in longitudinal prevalence(95% CI 1.07–1.25).In this assembled sample of 24- month-old children,the proportion of stunting attributed to 55 diarrhoea lepisodes before 24 months was 25% (95% CI 8–38%)and that attributed to being ill with diarrhoea for 52% of the time before 24 months was 18%(95%CI 1–31%).These observations are consistent with thehypothesis that a higher cumulative burden of diarrhoea increases the risk of stunting