Skip to main content
Article thumbnail
Location of Repository

Effects of Peppermint (Mentha piperita L.) Alcoholic Extract on Carbon Tetrachloride-induced Hepatotoxicity in Broiler Chickens Under Heat Stress Condition

By Khodadust MR, Samadi F, Ganji F, Jafari Ahangari Y and Asadi GH


In order to investigate the effects of peppermint (Mentha piperita L.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (CCl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. Factors included two levels of peppermint leaf alcoholic extract (0 and 2 mL/Kg body weight) and CCl4 (0 and 1 mL/Kg body weight). Results showed significant (P) interactions for body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR) on d 42 of the experiment. The alcoholic extract of peppermint leaf did not improve growth performance, whereas CCl4 worsened BWG and FCR (P). The interaction between peppermint extract and CCl4 indicated an ameliorative effect of peppermint extract on BWG and FCR (P). The interaction effects between peppermint extract and CCl4 significantly differed for blood serum concentrations of total protein, albumin, albumin:globulin ratio, glucose, triglyceride, total cholesterol, HDLC, LDLC, LDLC:HDLC ratio, and VLDLC as well as the amount of blood liver enzymes (P). Peppermint extract significantly increased blood serum concentrations of total protein, albumin, triglyceride and HDLC, whilst CCl4 decreased those concentrations (P). Blood serum concentrations of total cholesterol, LDLC, LDLC:HDLC ratio, VLDLC and glucose were decreased by peppermint extract, whereas those concentrations were increased by CCl4 (P). A significantly higher level of liver enzymes was found in blood serum of birds treated by CCl4 than those by peppermint extract (P). A moderate effect on blood serum liver enzymes was observed by the interaction between 2 mL of peppermint extract and 1 mL of CCl4 (P). Generally, this study indicated that in vivo administration of peppermint alcoholic extract ameliorated the adverse effects of CCl4 on growth performance and liver function, therefore it might be useful for the prevention of oxidative stress-induced hepatotoxicity in broilers

Topics: CCl4, Liver, Broiler, Peppermint, Oxidative stress, Animal culture, SF1-1100
Publisher: Gorgan University of Agricultural Sciences and Natural Resources
Year: 2015
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.