Skip to main content
Article thumbnail
Location of Repository

A new clinical feature associated with familial early-onset of dystonic-guttural tics: An unusual diagnosis of PANDAS

By Giovanna Vitaliti, Rosario R Trifiletti, Raffaele Falsaperla, Enrico Parano, Alberto Spalice and Piero Pavone


Until today there is a large debate about the existence of PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) or PANS (pediatric acute onset neuropsychiatric syndrome). These children usually have dramatic, "overnight" onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also have comorbid features of associated disorders. Herein, we report a family with an early onset of tics, with exclusively dystonic and guttural tics. All patients had a particularly strong excitement trigger. Two of the patients were shown to have signs suggestive of PANDAS and all family members were Group A beta-hemolytic Streptococcus (GABHS) carriers. The PANDAS spectrum is probably a group of disorders. We have described a PANDAS variant, in which the family seems to share common autoimmune pattern and may be viewed in the large spectrum of PANDAS

Topics: Childhood, familial, PANDAS spectrum, tics, Pediatrics, RJ1-570, Medicine, R, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245
Publisher: Medknow Publications
Year: 2014
DOI identifier: 10.4103/1817-1745.131497
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • http://www.pediatricneuroscien... (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.