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INTESTINAL NEURONAL DYSPLASIA, TYPE B - A CASE REPORT

By Lakshmi Vasavi and Kiran Kumar

Abstract

Intestinal\ud neuronal\ud dysplasia\ud (IND)\ud is\ud one\ud of\ud the\ud conditions\ud known\ud to\ud mimic\ud Hirschsprung’s\ud disease\ud (HD)\ud both\ud clinically\ud and\ud radiologically,\ud and\ud clinically\ud presents\ud with\ud intestinal\ud obstruction\ud in\ud pediatric\ud age\ud group.\ud Two\ud types\ud are\ud described.\ud 1\ud IND\ud Type\ud A\ud is\ud characterized\ud by\ud a\ud malformation\ud of\ud the\ud adrenergic\ud nerve\ud supply\ud to\ud the\ud blood\ud vessels\ud and\ud IND\ud Type\ud B,\ud in\ud which\ud the\ud submucosal\ud plexus\ud is\ud involved.\ud Giant\ud ganglia\ud are\ud involved\ud in\ud Type\ud B,\ud and\ud there\ud is\ud abnormal\ud morphology\ud of\ud the\ud nerve\ud cell\ud groups\ud and\ud nerve\ud cell\ud fibres.\ud 2\ud In\ud the\ud present\ud case,\ud diagnosis\ud was\ud established\ud mainly\ud by\ud biopsy\ud and\ud microscopic\ud examination\ud of\ud H&E\ud stained\ud sections,\ud which\ud show\ud increased\ud ganglion\ud cells\ud both\ud in\ud number\ud and\ud size,\ud and\ud confirmed\ud by\ud Cathepsin\ud D\ud immunostaining

Topics: Intestinal neuronal dysplasia, Ganglion cells, Hirschsprung’s disease, Cathepsin D, General works, R5-130.5
Publisher: Level Up Business Center
Year: 2015
OAI identifier: oai:doaj.org/article:e4c299923b54490b9d0cce36f74da89b
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