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By Lakshmi Vasavi and Kiran Kumar


Intestinal\ud neuronal\ud dysplasia\ud (IND)\ud is\ud one\ud of\ud the\ud conditions\ud known\ud to\ud mimic\ud Hirschsprung’s\ud disease\ud (HD)\ud both\ud clinically\ud and\ud radiologically,\ud and\ud clinically\ud presents\ud with\ud intestinal\ud obstruction\ud in\ud pediatric\ud age\ud group.\ud Two\ud types\ud are\ud described.\ud 1\ud IND\ud Type\ud A\ud is\ud characterized\ud by\ud a\ud malformation\ud of\ud the\ud adrenergic\ud nerve\ud supply\ud to\ud the\ud blood\ud vessels\ud and\ud IND\ud Type\ud B,\ud in\ud which\ud the\ud submucosal\ud plexus\ud is\ud involved.\ud Giant\ud ganglia\ud are\ud involved\ud in\ud Type\ud B,\ud and\ud there\ud is\ud abnormal\ud morphology\ud of\ud the\ud nerve\ud cell\ud groups\ud and\ud nerve\ud cell\ud fibres.\ud 2\ud In\ud the\ud present\ud case,\ud diagnosis\ud was\ud established\ud mainly\ud by\ud biopsy\ud and\ud microscopic\ud examination\ud of\ud H&E\ud stained\ud sections,\ud which\ud show\ud increased\ud ganglion\ud cells\ud both\ud in\ud number\ud and\ud size,\ud and\ud confirmed\ud by\ud Cathepsin\ud D\ud immunostaining

Topics: Intestinal neuronal dysplasia, Ganglion cells, Hirschsprung’s disease, Cathepsin D, General works, R5-130.5
Publisher: Level Up Business Center
Year: 2015
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