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Associations between common variants in iron-related genes with haematological traits in populations of African ancestry

By W.N. Gichohi-Wainaina, T. Tanaka, Wayne Towers, J.C.M. Verhoef, J. Veenemans, E.F. Talsma, J.L. Harryvan, M.V. Boekschoten, E.J.M. Feskens and A. Melse-Boonstra


BackgroundLarge genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations.MethodsWe tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels.ResultsIn the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P = <0.0001) in the meta analysis including the African cohorts only.ConclusionsIn all meta analyses, we only replicated 4 of the 20 single nucleotide polymorphisms reported to be associated with iron status in large GWA studies of European ancestry individuals. While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations

Topics: Afdeling Humane voeding, Human Nutrition (HNE), Humane Voeding, Human Nutrition, Humane Voeding & Gezondheid, Human Nutrition & Health, Leerstoelgroep Celbiologie en immunologie, Cell Biology and Immunology, Celbiologie en Immunologie, Cell Biology and Immunology, Chair Nutrition and Health over the Lifecourse, Chair Nutrition and Health over the Lifecourse, HNE Voeding en Gezondheid in de Levenscyclus, HNE Nutrition and Health over the Lifecourse, Wereldvoeding, Global Nutrition, HNE Facility, HNE Facility, HNE Facility, HNE Facility, OS&DAEB, OS&DAEB, Chair Nutrition Metabolism and Genomics, Chair Nutrition Metabolism and Genomics, HNE Voeding, Metabolisme en Genomics, HNE Nutrition, Metabolism and Genomics, Voeding, Metabolisme en Genomica, Nutrition, Metabolism and Genomics, VLAG, VLAG
Year: 2016
DOI identifier: 10.1371/journal.pone.0157996
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Provided by: Wageningen Yield
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