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Studies towards optimising the isolation of diplonine, a neurotoxin isolated from cultures of <i>Stenocarpella maydis</i> (Berk.) Sacc.

By Leendert D. Snyman, Bradley C. Flett and Rowina A. Schultz

Abstract

Diplonine, a mycotoxin that induces neurotoxic clinical signs in the guinea pig, resembling those occurring in cattle and sheep with diplodiosis, was isolated previously from a <em>Stenocarpella maydis</em><span>culture. Knowledge of the chemical properties of the toxin, which was characterised as a substituted ß-cyclopropylamino acid, enabled amendments in the present study to the initial steps of the isolation procedure. Extraction with water and fractionation by cation exchange chromatography improved the efficiency of isolation, potentially allowing the preparation of larger amounts of the toxin.</span

Topics: diplonine, diplodiosis, neuromycotoxin, Stenocarpella maydis, Veterinary medicine, SF600-1100
Publisher: AOSIS
Year: 2014
DOI identifier: 10.4102/ojvr.v81i1.765
OAI identifier: oai:doaj.org/article:4322016123974f99b773458e731bd345
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