Skip to main content
Article thumbnail
Location of Repository

Does NETosis contribute to the bacterial pathoadaptation in Cystic Fibrosis?

By Samir eRahman and Mihaela eGadjeva and Mihaela eGadjeva

Abstract

Significant advances in our understanding of neutrophil biology were made in the past few years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biological significance of NETosis in acute and chronic pathologic conditions. This review highlights the latest knowledge regarding NET structures, deployment, and function, with an emphasis on current understanding of NET proteomes, their conservation, and significance in the context of cystic fibrosis (CF), a condition characterized by excessive extracellular DNA/NET presence. We also discuss how our understanding of NETosis yields novel therapeutic approaches and their applicability to CF

Topics: Chromatin, Cystic Fibrosis, Histones, Neutrophils, Pseudomonas aeruginosa, NETs, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fimmu.2014.00378
OAI identifier: oai:doaj.org/article:cdd4f83295ad4e44a3e18319fa31d857
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-3224 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/cdd4f... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.