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Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state

By B. D. Glass, M. E. Brown, S. Daya, M. S. Worthington, P. Drummond, E. Antunes, M. Lebete, S. Anoopkumar-Dukie and D. Maharaj

Abstract

The photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac, piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification of the photodegradants investigated and mechanisms of photodegradation proposed. Selected cyclodextrins altered the photodegradation profiles of diclofenac, piroxicam, midazolam and nifedipine by either accelerating or retarding the rate of photodegradation and generating novel photodegradants

Topics: Renewable energy sources, TJ807-830
Publisher: Hindawi Publishing Corporation
Year: 2001
DOI identifier: 10.1155/S1110662X01000277
OAI identifier: oai:doaj.org/article:7dcffd9c62ab4e44938c2e30ae560aec
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