Location of Repository

Fullerene and apoptosis

By M. A. Orlova, T. P. Trofimova, A. P. Orlov, O. A. Shatalov, Yu. K. Napolov, A. A. Svistunov and V. P. Chekhonin

Abstract

<p>Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.</p

Topics: fullerenes, apoptosis, signaling pathway, Diseases of the blood and blood-forming organs, RC633-647.5
Publisher: ABV-press
Year: 2013
OAI identifier: oai:doaj.org/article:0df0582a0afc4412987075c4a32f3cb1
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2413-4023 (external link)
  • https://doaj.org/toc/1818-8346 (external link)
  • http://oncohematology.abvpress... (external link)
  • https://doaj.org/article/0df05... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.