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Some pathogenetic aspects of experimental pneumococcal meningitis in acute period

By V. V. Pilipenko, Yu. V. Lobzin, V. L. Pastushenkov, V. E. Karev and M. O. Volkova

Abstract

<p>Morphological displays of cerebral microcirculation derangements in a brain cortex with their semiquantitative estimation have been studied in experimental mice model of the first 24-72 hours period of pneumococcal meningitis.Also displays oxidative stress and activity antioxidative protectional system by means of definition of markers of these processes – malondialdehide, reduced glutathione and glucose-<br />6-phosphate-dehydrogenase activity have been investigated. The received results testify to morphological signs of the expressed derangements of cerebral microcirculation in a brain cortex already by first 24 hour of an experimental meningitis. The maximum expressiveness oxidative stress and activity antioxidative protectional system of reduced glutathione with the max activity of glucose-6-phosphatedehydrogenase in a mice brain cortex was noted at first 48<br />hour durations of experimental disease. Signs of irreversible changes of mice cortex neurons are not revealed at 24–72-hour duration of experimental pneumococcal meningitis.</p

Topics: пневмококковый менингит, экспериментальная модель, кора головного мозга, церебральные микроваскулярные нарушения, малоновый диальдегид, восстановленный глутатион, Infectious and parasitic diseases, RC109-216
Publisher: Journal Infectology
Year: 2011
OAI identifier: oai:doaj.org/article:38e5332275c64ce4837d13d751dede64
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