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Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells

By M. A. Taipov, Z. N. Nikiforova, O. M. Pavlova, I. A. Kudryavtsev, N. Ye. Arnotskaya and V. Ye. Shevchenko


The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen receptor-positive BC cells and to be linked to their metastatic potential. Smad4 and Smad2 apparently suppress COX-2 mRNA and protein synthesis and Smad7 is their antagonist and stimulates COX-2 formation. Smad2, Smad4, Smad7 proteins may be regarded as new potential targets for targeted BC therapy

Topics: breast cancer, cyclooxygenase-2 (COX-2), TGF-β1/SMAD signaling pathway, SMAD2, SMAD4, and SMAD7 genes, Smad4, Smad2, and Smad7 proteins, phosphorylated Smad2, inhibitors of COX-2, PGE2, human breast cancer cell lines MCF-7, BT-474, and ZR- 75-1, targets f, Gynecology and obstetrics, RG1-991
Publisher: ABV-press
Year: 2013
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