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Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

By Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, KristinA Hogquist, Michelle Wykes, Denis J Moss, Alan Rickinson, Henry H Balfour and Rajiv Khanna

Abstract

Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells

Topics: 1109 Insect Science, 2403 Immunology, 2404 Microbiology, 2406 Virology
Publisher: American Society for Microbiology
Year: 2015
DOI identifier: 10.1128/JVI.01293-15
OAI identifier: oai:espace.library.uq.edu.au:UQ:367888

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