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Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy

By H.J.C.M. (Dick) Sterenborg, J.W. (J.) de Wolf, M. (Miriam) Koning, B. (Bastiaan) Kruijt, A. (Angélique) van der Ploeg-van den Heuvel and D.J. (Dominic) Robinson

Abstract

The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments

Year: 2004
DOI identifier: 10.1364/OPEX.12.001873
OAI identifier: oai:repub.eur.nl:63905

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