Clinical evaluation of synthetic aperture harmonic imaging for scanning focal malignant liver lesions

Abstract

The purpose of the study was to perform a clinical comparison of synthetic aperture sequential beamformingtissue harmonic imaging (SASB-THI) sequences with a conventional imaging technique, dynamic receivefocusing with THI (DRF-THI). Both techniques used pulse inversion and were recorded interleaved using a commercialultrasound system (UltraView 800, BK Medical, Herlev, Denmark). Thirty-one patients with malignantfocal liver lesions (confirmed by biopsy or computed tomography/magnetic resonance) were scanned. Detectionof malignant focal liver lesions and preference of image quality were evaluated blinded off-line by eight radiologists.In total, 2,032 evaluations of 127 image sequences were completed. The sensitivity (77% SASB-THI, 76%DRF-THI, p 5 0.54) and specificity (71% SASB-THI, 72% DRF-THI, p 5 0.67) of detection of liver lesions andthe evaluation of image quality (p 5 0.63) did not differ between SASB-THI and DRF-THI. This study indicatesthe ability of SASB-THI in a true clinical setting.