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oaioai:centaur.reading.ac.uk:37106

Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles

Authors
Publication date
September 3, 2013
Publisher
'American Chemical Society (ACS)'
Doi
DOI:10.1021/ol402225d

Abstract

A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy

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    Central Archive at the University of Reading

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    This paper was published in Central Archive at the University of Reading.

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