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Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts

By Wei-Cheng Chen, Shih-Rong Hsieh, Chun-Hwei Chiu, Ban-Dar Hsu and Ying-Ming Liou


Epigallocatechin-3-gallate (EGCG) has been documented for its beneficial effects protecting oxidative stress to cardiac cells. Previously, we have shown the EGCG-mediated cardiac protection by attenuating reactive oxygen species and cytosolic Ca2+ in cardiac cells during oxidative stress and myocardial ischemia. Here, we aimed to seek a deeper elucidation of the molecular anti-oxidative capabilities of EGCG in an H2O2-induced oxidative stress model of myocardial ischemia injury using H9c2 rat cardiomyoblasts

Topics: Animals, Antioxidants, Apoptosis, Catechin, Cell Survival, Glycogen Synthase Kinase 3, Hydrogen Peroxide, Mitochondria, Myoblasts, Myocardium, Oxidative Stress, Phosphatidylinositol 3-Kinases, Phosphorylation, Rats, Reactive Oxygen Species, Signal Transduction
Year: 2015
DOI identifier: 10.1186/1423-0127-21-56
OAI identifier:

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