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Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension

By K. M. Dhasmana, W. A. B. Fokker and B. A. Spilker


A method for stimulating discrete segments of the spinal autonomic outflow in the pithed rat was found suitable for differentiating between the group of centrally acting antihypertensive agents α-methyldopa, clonidine and iproniazid and other antihypertensive compounds which additionally have peripheral vascular effects mediated via the peripheral sympathetic nerves

Topics: Short Communications
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Provided by: PubMed Central
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