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Morphine hyperthermia in the rat: Its attenuation by physostigmine

By M. Sharkawi

Abstract

1. In rats, a subcutaneous injection of morphine (2·5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0·1 mg/kg), but not of neostigmine (0·08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine

Topics: Drug Mechanisms
OAI identifier: oai:pubmedcentral.nih.gov:1665827
Provided by: PubMed Central
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