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Effect of M & B 17803A, a new β-adrenoceptor blocking agent, on the cardiovascular responses to tilting and to isoprenaline in man

By M. F. Cuthbert and K. Owusu-Ankomah

Abstract

1. DL-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M & B 17803A) was given to four healthy volunteers in single oral doses of up to 300 mg. There were no subjective effects and no significant alterations in the heart rate, systolic and diastolic blood pressure in the seated position or in the forced expiratory volume or in the electrocardiogram within 6 h of the dose. There were no abnormalities in haematological tests and estimations of the serum glutamyloxaloacetic transaminase

Topics: Clinical Pharmacology, Experimental Therapy
OAI identifier: oai:pubmedcentral.nih.gov:1665788
Provided by: PubMed Central
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