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Sleep produced by clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride)

By R. B. Holman, Elizabeth E. Shillito and Marthe Vogt


1. The dose of clonidine (given intravenously) required to elicit sleep in the young chick is 1/25th to 1/50th of an equiactive dose of noradrenaline. The approximate ED50 is 0·01 μmol/kg. Phentolamine (10-15 mg/kg, but not 5 mg/kg) antagonizes the action of both clonidine and noradrenaline

Topics: Systematic Pharmacology
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Provided by: PubMed Central
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