THE COMPARATIVE EVALUATION OF THE BIOTECHNOLOGICAL PROCESSES OF STERILIZATION AND PRESERVATION, TO BE USED IN THE PRODUCTION OF THE CHOLERA BIVALENT CHEMICAL TABLETTE VACCINE

Abstract

The method of preservation, using the merthyolate of the high-immunogenous fractions, included in the composition of the cholera vaccine, has been offered. The antigenic composition of the preparation components, obtained by the improved technology, has been studied. The harmfulness of the given method of preservation of the microorganism has been shown. The biotechnological ways of the mass receiving the vaccine with use of the optimum exposition and minimum preserving dose of merthyolate have been developed. The experimentally-production series of the cholera chemical bivalent tabletted vaccine, obtained with use of the merthyolate as the preservant, was permitted by the GISKAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio