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By Nataliya Vladimirovna Vostretsova


The work covers 57 derivatives of 7-alkyl-8-halogen-3-melthyl xantine. The aim is to study the pharmacological activity dependence upon the chemical structure, to discover the high-effective substances among 57 derivatives of 7-alkyl-8-halogen-3-methyl xantine. The structural-pharmacological analysis of the pharmacological activity types among 57 newly synthesized original derivatides of 7,8-di-substituted-3-methyl xantine has been performed firstly with use of the computer forecast.The pharmacological activity and some harmlessness parameters of the new pharmacological substance brobexaverine (7-benzyl-8-bromine-3-methyl xantine) have been studied, and its hypotensive and de-priming activity has been proved. The investigation results have been introduced into the educational and scientific process in the pharmacotherapy and pharmacokinetics departments of the Ukrainian Pharmaceutical Academy. The documentation for presentation into the Pharmaceutical Committee has been prepared for a purpose to obtain the permit of performing clinic tests. Application field: pharmaceuticsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Topics: 06O - Pharmacology, pharmacy, pharmaceutical chemistry, BIOLOGY, MEDICINE AND HEALTHCARE
Year: 1992
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Provided by: OpenGrey Repository
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