Calcium signaling in eucaryotic cells: regulation mechanisms and certain functions

Abstract

The investigation is concerned with calmodulin and dihydropyridine-sensitive calcium canals of the plasmatic membranes of man's fibroblasts, neuroblastomes of mice and cerebral cortices of rats. The object of investigation is comprehensive revelation of the mechanisms of regulation of calcium signaling at the level of calmodulin and calcium canals of the plasmatic membrane and probable functions of these canals. The researchers have discovered three new mechanisms of regulation of activity of calmodulin by polypeptide factors, revealed the high plasticity of the calcium canal system with respect to the functional state of the cell and role of these canals in the mechanisms of formation of memory, developed a quantitative method of determining the activity of growth factors and new approaches to the problem of determination of the activity of nootropic preparations, disclosed the effectiveness of using nootropic preparations for the purpose of correcting the side-effect produced by the antianginal preparations that block the Ca-canals and discovered two glycin derivatives that may be employed as a basis for the creation of novel neurotropic preparationsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio