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In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis

By Lucio Vera-Cabrera, Eva Gonzalez, Adrian Rendon, Jorge Ocampo-Candiani, Oliverio Welsh, Victor M. Velazquez-Moreno, Sung Hak Choi and Carmen Molina-Torres

Abstract

The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC90 of 1 μg/ml and an MIC50 of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis

Topics: Susceptibility
Publisher: American Society for Microbiology
OAI identifier: oai:pubmedcentral.nih.gov:1563545
Provided by: PubMed Central
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