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Chloramphenicol and phenobarbitone--a drug interaction.

By R A Bloxham, G M Durbin, T Johnson and M H Winterborn


Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed

Topics: Research Article
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