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Stem cell-derived cardiomyocytes after bone marrow and heart transplantation

By R.A. de Weger, I. Verbrugge, A.H. Bruggink, M.F.M. van Oosterhout, Y. de Souza, D.F. van Wichen, F.H.J. Gmelig Meyling, N. de Jonge and L.F. Verdonck


Cardiomyocytes are a stable cell population with only\ud limited potential for renewal after injury. Tissue regeneration\ud may be due to infiltration of stem cells, which\ud differentiate into cardiomyocytes. We have analysed the\ud influx of stem cells in the heart of patients who received\ud either a gender-mismatched BMT (male donor to female\ud recipient) or a gender-mismatched cardiac transplant\ud (HTX; female donor to male recipient). The proportion\ud of infiltrating cells was determined by Y-chromosome\ud in situ hybridization combined with immunohistochemical\ud cell characterization. In BM transplanted patients and in\ud cardiac allotransplant recipients, cardiomyocytes of\ud apparent BM origin were detected. The proportions were\ud similar in both groups and amounted up to 1% of all\ud cardiomyocytes. The number of stem cell-derived cardiomyocytes\ud did not alter significantly in time, but were\ud relatively high in cases where large numbers of BMderived\ud Y-chromosome-positive infiltrating inflammatory\ud cells were present. The number of Y-chromosome-positive\ud endothelial cells was small and present only in small blood\ud vessels. The number of BM-derived cardiomyocytes in\ud both BMT and HTX is not significantly different between\ud the two types of transplantation and is at most 1

Topics: Geneeskunde, stem cells, heart transplantation, cardiomyocytes
Year: 2008
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