Cardiomyocytes are a stable cell population with only
limited potential for renewal after injury. Tissue regeneration
may be due to infiltration of stem cells, which
differentiate into cardiomyocytes. We have analysed the
influx of stem cells in the heart of patients who received
either a gender-mismatched BMT (male donor to female
recipient) or a gender-mismatched cardiac transplant
(HTX; female donor to male recipient). The proportion
of infiltrating cells was determined by Y-chromosome
in situ hybridization combined with immunohistochemical
cell characterization. In BM transplanted patients and in
cardiac allotransplant recipients, cardiomyocytes of
apparent BM origin were detected. The proportions were
similar in both groups and amounted up to 1% of all
cardiomyocytes. The number of stem cell-derived cardiomyocytes
did not alter significantly in time, but were
relatively high in cases where large numbers of BMderived
Y-chromosome-positive infiltrating inflammatory
cells were present. The number of Y-chromosome-positive
endothelial cells was small and present only in small blood
vessels. The number of BM-derived cardiomyocytes in
both BMT and HTX is not significantly different between
the two types of transplantation and is at most 1
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.